Altered oscillatory brain dynamics after repeated traumatic stress

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Altered oscillatory brain dynamics after repeated traumatic stress

BACKGROUND Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness. METHODS Using magnetoe...

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Imaging the trauma: altered cortical dynamics after repeated traumatic stress

In patients with posttraumatic stress disorder (PTSD), we found evidence of altered systemic cerebral functioning by mapping generators of slow waves produced within circumscribed brain regions. Such focal activities have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness. Using magnetoencephalographic (MEG-based) source imaging, we...

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Repeated Mild Traumatic Brain Injury

Mild traumatic brain injury (mTBI) represents a significant public healthcare concern, accounting for the majority of all head injuries. While symptoms are generally transient, some patients go on to experience long-term cognitive impairments and additional mild impacts can result in exacerbated and persisting negative outcomes. To date, studies using a range of experimental models have reporte...

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Analysis of functional pathways altered after mild traumatic brain injury.

Concussive injury (or mild traumatic brain injury; mTBI) can exhibit features of focal or diffuse injury patterns. We compared and contrasted the cellular and molecular responses after mild controlled cortical impact (mCCI; a focal injury) or fluid percussion injury (FPI; a diffuse injury) in rats. The rationale for this comparative analysis was to investigate the brain's response to mild diffu...

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Post-traumatic amnesia and the nature of post-traumatic stress disorder after mild traumatic brain injury.

The prevalence and nature of post-traumatic stress disorder (PTSD) following mild traumatic brain injury (MTBI) is controversial because of the apparent paradox of suffering PTSD with impaired memory for the traumatic event. In this study, 1167 survivors of traumatic injury (MTBI: 459, No TBI: 708) were assessed for PTSD symptoms and post-traumatic amnesia during hospitalization, and were subse...

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ژورنال

عنوان ژورنال: BMC Psychiatry

سال: 2007

ISSN: 1471-244X

DOI: 10.1186/1471-244x-7-56